Maybe you just need a solid partner! If you still haven't finished it by this weekend we can group. I'll be out of town wed & thurs until like 7pm est so pretty much anytime after that I should be home.
the way I just beat it first try was play as Swann and just keep your tanks in the big dropship things hercules or whatever. played against air terran so just had 1 ship full of tanks and then had goliath sci vessel hellbat for anti air/fodder/money dump. just back up vessels and tanks when hybrids come so they just fight your fodder mineral hellbats and you wont lose hardly anything to nukes. I built 1 missile turret for detection just in case at each entrance and his upgraded turrets are so strong the enemy had trouble killing them even at the end so you can probably just dump some money into that for dps if you feel like it.
Had a Raynor partner and he just mined up his side and then went bio with it but was a little more reckless with losing stuff to nukes.
Raynor: Clearly 1st. Mines/Turrets/Vikings/optional Tanks cover every possible attack path and mostly ignores Nukes.
Alarak: Clearly 2nd. Can ignore Nukes with Mind Blast's long range. However, he's not as omnipresent as Raynor and struggles a bit more than him at controlling the entire map.
Swann: Clearly 3rd. Long range on all his primary units helps a lot against. Turrets of all kinds are useful late-game. The usually long ramp-up time doesn't matter here as he can easily clear the first few waves on his own.
Artanis: It gets a bit hazy from here on out. Artanis is good for both his Guardian Shell and his Tempests. Even Scourge-waves are manageable here with calldowns.
Karax: The building-stealing mutation doesn't matter as much as you would think. Karax's spear and Carriers help kill Hybrids before they get in range to Nuke your buildings. Struggles a tiny bit at clearing Void Thrashers.
Zagara: Amazing early game as Zagara can solo the start. Amazing mid-game as Banelings/Scourge are perfect counters to Nukes. Struggles a bit late game, especially if your partner is bad as she can run out of money. Unfortunately, Bile Launchers aren't as amazing here due to Nukes killing them, but they're still useful.
Abathur: Brutalisks tank Nukes and Guardians outrange them.
Nova: Nova destroys ground-based waves due to Mines, but struggles a lot more against air, especially air Hybrids. She has no amazing way to kill a large number of them easily as Goliaths and Ghosts are good against air Hybrids but they're nowhere near completely dominating.
Stukov: Struggles in general as Nukes can clear large numbers of Infested. Struggles against air as he has no way to kill air Hybrids without suffering severe losses.
Kerrigan: Kerrigan can't effectively deal with air Hybrids at all and also has some problems dealing with ground Hybrids.
Vorazun: Vorazun is dead last for the 4th week in a row. She simply has no good way to consistently deal with Hybrid Nukes.
I agree with some parts of the list, but I do feel that both Nova and Zagara (when properly controlled) should be higher up on the list. When playing Nova I went for bio+ravens and put a lot of mastery points inte Nova energy regeneration. Raven turrets distracted the hybrids (even air hybrids to some extent), while ghost cast EMP and snipes(manually), Nova sniped and ravens spammed the hunter seeker missiles. He'll you can even cast your airstrike if you like. Sure it requires some apm and skill, but it's very reliable.
For Zagara I chose to build only zerglings, banelings and scourges. Found myself floating minerals in all the games I played with here, even when I carried. I was kind of careful not to lose units to Nukes needlessly. Rushed all baneling upgrades and tried to move command the banelings to do more splash damage rather than just a-moving. Same as with Nova, really strong and reliable with the right strategy and control.
Thanks. I gave Swann a shot with max range 3/3 goliaths and walled in two of the entrances with engy bays, and had a competent 90 mastery Artanis that went air, and it was much easier. I had vessels following his army and mine and we kept everything at full HP.
I used Zagara and my partner used Artanis. Super easy especially bc Artanis which shields units when they are about to die. This saves the majority of my army from dying when the Hybrid dies and drops a nuke.