EDT 05:45 CEST 11:45 KST 18:45

Streams: 55 live
32833 total viewers

Active: 7717
Pizza Meter
[WCS KR] Innovation vs. Sy…
[WCS AM] Ro16 Group C Prev…
Bruno Community Q&A
Beyond the Summit and TL S…
[WCS KR] Code S Recap/Code…
HerO, Revival Interviews -…
[SPL] Round 5 Week 4 Start…
viOLet forfeits WCS AM due…
FXOpen acquires Seed from …
Crank, mOOnGLaDe interview…
LGD.cn and RaTtLeSnAkE Adv…
GomTV: about the gamespeed…
Get 50% off Papa John's pi…
TL Advertising Features
[TV/BOOK] *SPOILERS* Gam…
Best way to "move on" af…
[TV] Star Trek: Deep Spa…
Korean Music Discussion
[SFW] Random pics that m…
BarcraftOslo WCS Europe Fi…
Seoul LoL allstars Meetup …
The Automated Ban List
Barcraft Ludwigshafen
TL.net Ten Commandments
Azubu.Symbol Fanclub
Naniwa FanClub!
[Stream] Najzmajs
[Stream] theognis
What mouse/pad does your f…
Computer screen distorted …
Same SSID different places…
Mechanical Keyboard Guide
The Ultimate Headphone/Aud…
viOLet forfeits WCS AM d…
WCS AM - Ro16 Interviews…
HerO, Revival Interviews…
Hellokitty Top 16 GM NA …
[Interview] Code S PM 20…
Post your Papa John's Es…
[Code S] Ro4 Day 2 WCS Kor…
[WCS AM] RO16 Group C Prem…
[ATC] Quantic vs. Milleniu…
Numericable M-House Cup 2 …
SC2 LR Resources
[D] Rebuff Snipe?
[G] TheStaircase - An Alte…
CatZ CC first counter - a …
The HotS Protoss Help Me T…
SC2 Strategy Recommended T…
[A] Starbow
[M] (2) ESV Ravage by Iron…
TeamLiquid Map Contest Fin…
[D] Favorite Maps that Did…
[A] Peepmode: New maps, ne…
Who is Who
Toronto Dota Community.
General Discussion
Bruno Community Q&A
Dota 2 QQ thread
The International Intera…
[The International] Easter…
[D2L] EG vs. Na'Vi & VP
Liquid Pasture Community L…
Perfect World's Dota 2 Su…
Starladder Season 6
[H] Night Stalker
[G] In-Game Dota Guide for…
Simple Questions, Simple A…
[G]uide to Lifestealer
[G] Clockwerk, The Offlani…
2 Artificial Intelligenc…
[D] New BW Server
[Update] itemBay SSL Gra…
DES Sonic Interview 5/18…
Hiya - Highlight Video
[SOSPA] Event Matches
[SRT] Ro16 Group B
C Ranks Teamleague Season 1
[GC S3] Gambit's Cup Semif…
Gem League II
D Ranks Teamleague Season 4
Practice Partner Thread
Challenger map on Starcraf…
Simple Questions, Simple A…
Increasing APM/EAPM
Steam Sales Thread
EVE Corporation
World of Tanks
Magic: The Gathering Onl…
Dungeon Crawl Stone Soup
Anyone Diamond want to joi…
[LoL Stream] Entenzwerg
The Shikyo Memorial for QQ…
[LCS] All-Star Tournament
[OGN] Olympus The Champion…
[LoL] General Stream Thread
[Champion] Nunu
[Guide] Montegomery's Supe…
[Champion] Nidalee
Barbarian - Builds/Discuss…
The: What is my item worth?
[G] Hardcore
[T] Bastard "Mini" Mafia!
[M][N] Les Mafia
Carnival Cruise Mafia
Questions & Answers
TL Health and Fitness Init…
Running Thread
Leta - Movie
Michael - skyline
Anytime - Beast
By.Hero - Shuttle
Anytime - Pusan

Website Feedback

Closed Threads

IRC Chat
irc.quakenet.org #teamliquid

IRC Web Client

TeamSpeak 3 (40 users)

Old dads linked to autism

Forum Index > General Forum 1 2 3 4 All
 
 GT350   United States. August 24 2012 04:48. Posts 270
Profile # 
Children of older dads are more likely to develop diseases such as schizophrenia and autism than those of younger fathers, new research suggests.

Older men pass on more new DNA mutations - de novo mutations - to their kids than younger dads, putting their children at a higher risk for developmental issues, according to a study published Wednesday in the scientific journal Nature.


Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent–offspring trios at high coverage. We show that in our samples, with an average father’s age of 29.7, the average de novo mutation rate is 1.20 × 10−8 per nucleotide per generation. Most notably, the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child. The effect is an increase of about two mutations per year. An exponential model estimates paternal mutations doubling every 16.5 years. After accounting for random Poisson variation, father’s age is estimated to explain nearly all of the remaining variation in the de novo mutation counts. These observations shed light on the importance of the father’s age on the risk of diseases such as schizophrenia and autism.


http://www.nature.com/nature/journal/v488/n7412/full/nature11396.html
http://healthland.time.com/2012/08/23/older-fathers-linked-to-kids-autism-and-schizophrenia-risk/
Old Post

 
 Cokefreak   Finland. August 24 2012 04:50. Posts 5665
Profile # 
Well I do feel quite schizophrenic at times, my dad was 49 when I was born. Interesting study, have to read through it tomorrow when I'm a bit more awake.
I am the 4%, http://www.teamliquid.net/forum/viewpost.php?post_id=17208214 Also known as Heather~ a cancer to teamliquid and probably a terrible, possibly bed wetting, person.
Old Post

 
 farvacola   United States. August 24 2012 04:51. Posts 5501
Profile Blog # 
Well this seems reasonable, we're already aware of how the mother's age affects the likelihood of certain diseases, it would follow that a father's age is similarly impactful.
"Hey colaboy, you made the same exact post to me in the 2012 election thread. I am so glad that TL has thread constables!"
Old Post

 
 ddrddrddrddr   August 24 2012 04:51. Posts 1232
Profile # 
Well, if it's just mutations we're talking about, then it also speeds up evolution if the entire society's women go for older men right?
Old Post

 
 Zahir   United States. August 24 2012 04:53. Posts 908
Profile # 
Makes sense to me. I've often heard people say that children born of young couples tend to be fitter.
What is best? To crush the Zerg, see them driven before you, and to hear the lamentations of the Protoss.
Old Post

 
 Demonhunter04   August 24 2012 04:59. Posts 1470
Profile # 

On August 24 2012 04:51 farvacola wrote:
Well this seems reasonable, we're already aware of how the mother's age affects the likelihood of certain diseases, it would follow that a father's age is similarly impactful.


Not really, since the child grows in the mother's body.


On August 24 2012 04:51 ddrddrddrddr wrote:
Well, if it's just mutations we're talking about, then it also speeds up evolution if the entire society's women go for older men right?


Yes. For that matter, the natural lifespan of our species is attributed to older men having more children over their lifetime than men who did not live as long. Genes for lifespan are not sex-linked, so both genders benefit.

EDIT: Evolution is mainly spurred by the survival of the most adapted, more so than mutations.

Also, the mutation rate is incredibly low to begin with, so even doubling it a few times makes little difference.
Last edit: 2012-08-24 05:01:06
"If you don't drop sweat today, you will drop tears tomorrow" - SlayerSMMA
Old Post

 
 farvacola   United States. August 24 2012 05:04. Posts 5501
Profile Blog # 

On August 24 2012 04:59 Demonhunter04 wrote:

Show nested quote +



Not really, since the child grows in the mother's body.


Show nested quote +



Yes. For that matter, the natural lifespan of our species is attributed to older men having more children over their lifetime than men who did not live as long. Genes for lifespan are not sex-linked, so both genders benefit.

EDIT: Evolution is mainly spurred by the survival of the most adapted, more so than mutations.

Also, the mutation rate is incredibly low to begin with, so even doubling it a few times makes little difference.

Yes really, one of the most prevalent maternal age related issues with pregnancy is an increased risk of downs syndrome, which is a chromosomal defect, meaning we understand age and the quality of genetic material to be highly interrelated. The same can be clearly be applied to the quality of male genetic material.
"Hey colaboy, you made the same exact post to me in the 2012 election thread. I am so glad that TL has thread constables!"
Old Post

 
 Demonhunter04   August 24 2012 05:23. Posts 1470
Profile # 

On August 24 2012 05:04 farvacola wrote:

Show nested quote +


Yes really, one of the most prevalent maternal age related issues with pregnancy is an increased risk of downs syndrome, which is a chromosomal defect, meaning we understand age and the quality of genetic material to be highly interrelated. The same can be clearly be applied to the quality of male genetic material.


Not really, since a woman is born with all the eggs she will ever have, and so they age over time. Men replace sperm daily.
"If you don't drop sweat today, you will drop tears tomorrow" - SlayerSMMA
Old Post

 
 Flamingo777   United States. August 24 2012 05:25. Posts 1140
Profile # 
I'd modify the title to include schizophrenia, or at least broaden it to like "Older dads may increase the risk of mental disorders in children," or something like that.
Old Post

 
 IamBach   United States. August 24 2012 05:27. Posts 1058
Profile Blog # 
That sucks for old dads now. I would hate to think I was responsible for a defect in my child.
Just listen http://www.youtube.com/watch?v=__lCZeePG48
Old Post

 
 farvacola   United States. August 24 2012 05:32. Posts 5501
Profile Blog # 

On August 24 2012 05:23 Demonhunter04 wrote:

Show nested quote +



Not really, since a woman is born with all the eggs she will ever have, and so they age over time. Men replace sperm daily.

The testicles age over time just as eggs do.
"Hey colaboy, you made the same exact post to me in the 2012 election thread. I am so glad that TL has thread constables!"
Old Post

 
 Demonhunter04   August 24 2012 05:34. Posts 1470
Profile # 

On August 24 2012 05:32 farvacola wrote:

Show nested quote +


The testicles age over time just as eggs do.


The sperm themselves are replaced. And the womb also ages over time.
"If you don't drop sweat today, you will drop tears tomorrow" - SlayerSMMA
Old Post

 
 Alpino   Brazil. August 24 2012 05:51. Posts 2584
Profile # 

On August 24 2012 04:59 Demonhunter04 wrote:

Show nested quote +



Not really, since the child grows in the mother's body.


Show nested quote +



Yes. For that matter, the natural lifespan of our species is attributed to older men having more children over their lifetime than men who did not live as long. Genes for lifespan are not sex-linked, so both genders benefit.

EDIT: Evolution is mainly spurred by the survival of the most adapted, more so than mutations.

Also, the mutation rate is incredibly low to begin with, so even doubling it a few times makes little difference.


Adaptation can come only from mutations coinciding with what was needed.
no gods/ no masters/ no borders/ no wars
Old Post

  Bahamut1337   Ghana. August 24 2012 05:54. Posts 205Profile # 
Would explain a lot ( possibly ) regarding the amount of disabled people which is increasing in the Netherlands ( average age of dads up, disabilities due to it up? )
Old Post

 
 Demonhunter04   August 24 2012 05:58. Posts 1470
Profile # 

On August 24 2012 05:51 Alpino wrote:

Show nested quote +



Adaptation can come only from mutations coinciding with what was needed.


Unless the phenotype already exists in the population.
"If you don't drop sweat today, you will drop tears tomorrow" - SlayerSMMA
Old Post

 
 mcc   Czech Republic. August 24 2012 06:08. Posts 3751
Profile # 

On August 24 2012 05:34 Demonhunter04 wrote:

Show nested quote +



The sperm themselves are replaced. And the womb also ages over time.

Are you actually arguing that father's age does not have measurable impact on child's health issues or that it has but much less than mother's ? Because the former is clearly contradicted by the study from OP, the latter seems like a reasonable assumption so far.
Old Post

 
 mcc   Czech Republic. August 24 2012 06:09. Posts 3751
Profile # 

On August 24 2012 05:58 Demonhunter04 wrote:

Show nested quote +



Unless the phenotype already exists in the population.

You mean genotype ?
Old Post

 
 Shakattak   Canada. August 24 2012 06:10. Posts 911
Profile Blog # 
I am a high functioning Austic my dad was in his mid thirties when he and my mom had me.
Team Overklocked Gaming ! That man is the noblest creature may be inferred from the fact that no other creature has contested this claim. - G.C. Lichtenberg
Old Post

 
 Demonhunter04   August 24 2012 06:11. Posts 1470
Profile # 

On August 24 2012 06:09 mcc wrote:

Show nested quote +


You mean genotype ?


No, I meant phenotype.
"If you don't drop sweat today, you will drop tears tomorrow" - SlayerSMMA
Old Post

 
 Psychonian   United States. August 24 2012 06:13. Posts 492
Profile # 
Hmm, let's see. My dad was 38 when I was born and I have been diagnosed with PDD, ADHD, and High Functioning Autism. So this could be a factor. I'll have to read through it.

Also, Mod needs to change title to 'Old fathers linked to mental disorders' or maybe 'Old fathers linked to schizophrenia, autism'.



On August 24 2012 06:10 ShakAttaK wrote:
I am a high functioning Austic my dad was in his mid thirties when he and my mom had me.


Yeah, as I said in my post, he was 38, mom was 36. So, something to think about.
Last edit: 2012-08-24 06:14:58
BronzeKnee United States. May 07 2013 09:48. If this Oracle walks into the Widow Mine... BronzeKnee United States. May 07 2013 09:49. Sigh. -Heart vs. HelloKitty
Old Post

1 2 3 4 All
Please log in or register to reply.
 
Refresh
StarCraft: Brood War
StarCraft 2
Dota 2
Other Notable Streams
[ Show 45 non-featured ]

» Recent SC2 Results
» Premier SC2 Tournaments
Sidebar Settings...

The Little App Factory



The opinions expressed by our users do not reflect the official position of TeamLiquid.net or its staff.

Advertising | Jobs | Privacy | Terms Of Use | Contact Us

Original banner artwork: Jim Warren. Ad tag: TF_US.
The contents of this webpage are copyright © 2002-2013 Teamliquid.net. All Rights Reserved